MAPKBP1 Rabbit Polyclonal Antibody (CAB2626)
- SKU:
- CAB2626
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | MAPKBP1 Rabbit Polyclonal Antibody |
SKU: | CAB2626 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MAPKBP1 (NP_001122080.1). |
Sequence: | MAVE GSTI TSRI KNLL RSPS IKLR RSKA GNRR EDLS SKVT LEKV LGIT VSGG RGLA CDPR SGLV AYPA GCVV VLFN PRKH KQHH ILNS SRKT ITAL AFSP |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | JNKBP1; NPHP20; JNKBP-1; MAPKBP1 |
Positive Sample: | Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, mitotic spindle pole, nucleolus, nucleoplasm |
Calculated MW: | 164kDa |
Observed MW: | 164kDa |
This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients.
Purification Method: | Affinity purification |
Gene ID: | 23005 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |