The MAPKBP1 Polyclonal Antibody (CAB2626) is a valuable tool for researchers studying the MAPKBP1 protein, which plays a crucial role in cell signaling pathways and immune regulation. This antibody, produced in rabbits, has high reactivity with human samples and is ideal for use in Western blot applications. By specifically binding to the MAPKBP1 protein, researchers can accurately detect and analyze its expression in a variety of cell types.MAPKBP1 is involved in regulating the activity of MAP kinase pathways, which are essential for cell growth, differentiation, and response to stress. Dysregulation of MAPK signaling is implicated in various diseases, including cancer, neurodegenerative disorders, and inflammatory conditions.
By studying the function of MAPKBP1, researchers can gain insight into the mechanisms underlying these diseases and potentially identify novel therapeutic targets.Overall, the MAPKBP1 Polyclonal Antibody is a valuable tool for researchers interested in understanding the role of MAPKBP1 in cellular processes and disease pathogenesis. Its high specificity and sensitivity make it a reliable reagent for immunology, cancer research, and other areas of biomedical investigation.
Product Name:
MAPKBP1 Rabbit Polyclonal Antibody
SKU:
CAB2626
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MAPKBP1 (NP_001122080.1).
This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients.
Purification Method:
Affinity purification
Gene ID:
23005
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MAPKBP1 antibody (CAB2626) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
