The MAPK9 Polyclonal Antibody (PACO22056) is a valuable tool for researchers studying the mitogen-activated protein kinase 9 (MAPK9) protein. MAPK9, also known as c-Jun N-terminal kinase 2 (JNK2), is a member of the MAPK family involved in signal transduction pathways that regulate various cellular processes such as cell growth, differentiation, and apoptosis.This antibody is raised in rabbits and exhibits high reactivity with human samples, making it suitable for Western blot applications. By specifically binding to the MAPK9 protein, researchers can effectively detect and analyze MAPK9 expression in different cell types. This makes the antibody well-suited for investigations in areas such as cell signaling, cancer research, and drug development.MAPK9 plays a crucial role in mediating cellular responses to stress and inflammatory signals, and dysregulation of its activity has been implicated in various diseases, including cancer, neurodegenerative disorders, and inflammation-related conditions.
Understanding the functions and regulation of MAPK9 is essential for unraveling its role in disease pathogenesis and identifying potential therapeutic targets.Overall, the MAPK9 Polyclonal Antibody (PACO22056) is a valuable tool for researchers aiming to explore the complex functions of MAPK9 and its involvement in various physiological and pathological processes. Its high specificity and sensitivity make it a reliable choice for studies aiming to uncover new insights into the role of MAPK9 in health
Antibody Name:
MAPK9 Antibody (PACO22056)
Antibody SKU:
PACO22056
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from internal of human MAPK9.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from A549 cells and RAW264.7 cells, using MAPK9 antibody.
Background:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
Synonyms:
Mitogen-activated protein kinase 9; EC 2.7.11.24; Stress-activated protein kinase JNK2; c-Jun N-terminal kinase 2; JNK-55
