JNK2 Polyclonal Antibody (CAB1251)
- SKU:
- CAB1251
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | JNK2 Polyclonal Antibody |
SKU: | CAB1251 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-424 of human JNK2 (NP_002743.3). |
Sequence: | MSDS KCDS QFYS VQVA DSTF TVLK RYQQ LKPI GSGA QGIV CAAF DTVL GINV AVKK LSRP FQNQ THAK RAYR ELVL LKCV NHKN IISL LNVF TPQK TLEE FQDV YLVM ELMD ANLC QVIH MELD HERM SYLL YQML CGIK HLHS AGII HRDL KPSN IVVK SDCT LKIL DFGL ARTA CTNF MMTP YVVT RYYR APEV ILGM GYKE NVDI WSVG CIMG ELVK GCVI FQGT DHID QWNK VIEQ LGTP SAEF MKKL QPTV RNYV ENRP KYPG IKFE ELFP DWIF PSES ERDK IKTS QARD LLSK MLVI DPDK RISV DEAL RHPY ITVW YDPA EAEA PPPQ IYDA QLEE REHA IEEW KELI YKEV MDWE ERSK NGVV KDQP SDAA VSSN ATPS QSSS INDI SSMS TEQT LASD TDSS LDAS TGPL EGCR |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | JNK2; SAPK; p54a; JNK2A; JNK2B; PRKM9; JNK-55; SAPK1a; JNK2BETA; p54aSAPK; JNK2ALPHA; K2 |
Positive Sample: | MCF-7,DU145,THP-1,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 48kDa |
Observed MW: | 54kDa |
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
Purification Method: | Affinity purification |
Gene ID: | 5601 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |