The MAPK8IP2 Polyclonal Antibody (PACO45641) is a valuable tool for researchers studying the MAPK8IP2 protein, which plays a crucial role in various cellular processes including signal transduction, cell proliferation, and apoptosis. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.MAPK8IP2, also known as JIP2, is a scaffolding protein that acts as a crucial mediator in the JNK signaling pathway, regulating gene expression and cell survival. By targeting MAPK8IP2, researchers can explore its role in cancer development, neurodegenerative diseases, and other disorders where dysregulation of signaling pathways is implicated.
The MAPK8IP2 Polyclonal Antibody offers researchers a powerful tool to detect and analyze MAPK8IP2 expression in various cell types, allowing for a deeper understanding of its function and potential therapeutic implications. By studying MAPK8IP2, researchers can uncover new insights into disease mechanisms and identify novel targets for drug development.
Antibody Name:
MAPK8IP2 Antibody (PACO45641)
Antibody SKU:
PACO45641
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Human
Immunogen:
Recombinant Human C-Jun-amino-terminal kinase-interacting protein 2 protein (470-570AA)
Form:
Liquid
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:
Antigen Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot. All lanes: MAPK8IP2 antibody at 2.85µg/ml. Lane 1: U251 whole cell lysate. Lane 2: A549 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 88, 85, 65, 50 kDa. Observed band size: 88 kDa..
Background:
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).
Synonyms:
C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2), MAPK8IP2, IB2 JIP2 PRKM8IPL
UniProt Protein Function:
MAPK8IP2: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Belongs to the JIP scaffold family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Protein kinase, regulatory subunit; Activator
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: protein complex; cell soma; cytoplasm
Molecular Function:MAP-kinase scaffold activity; protein binding; kinesin binding; beta-amyloid binding; protein complex binding; structural molecule activity; protein kinase binding; protein kinase activator activity
Biological Process: nonassociative learning; regulation of synaptic transmission, glutamatergic; behavioral fear response; dendrite morphogenesis; MAPKKK cascade; mating behavior; signal complex assembly; social behavior; regulation of JNK cascade; positive regulation of stress-activated MAPK cascade; positive regulation of protein kinase activity; JNK cascade; regulation of receptor activity; regulation of excitatory postsynaptic membrane potential
NCBI Summary:
The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
