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MAPK8IP2 Antibody (PACO03714)

SKU:
PACO03714
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$323

Description

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MAPK8IP2 Antibody (PACO03714)

The MAPK8IP2 Polyclonal Antibody (PACO03714) is a valuable tool for researchers studying MAPK8IP2, a protein involved in various cellular processes, including cell proliferation, differentiation, and apoptosis. This antibody, generated in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By targeting the MAPK8IP2 protein, this antibody enables the detection and analysis of MAPK8IP2 expression in different cell types, making it an ideal choice for studies in cell biology and cancer research.

MAPK8IP2, also known as JIP2, is a scaffold protein that interacts with various signaling molecules, including kinases and GTPases, to modulate signal transduction pathways. Its role in cell signaling makes it a compelling target for investigation in the context of cancer, neurodegenerative diseases, and other pathological conditions. Understanding the function of MAPK8IP2 can provide valuable insights into the underlying mechanisms of these diseases and may lead to the development of novel therapeutic strategies targeting this protein.

Antibody Name:MAPK8IP2 Antibody
Antibody SKU:PACO03714
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the C-terminal region of human JIP-2.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:MAPK8IP2; IB2; JIP2; PRKM8IPL; C-Jun-amino-terminal kinase-interacting protein 2; JIP-2; JNK-interacting protein 2; Islet-brain-2; IB-2; JNK MAP kinase scaffold protein 2; Mitogen-activated protein kinase 8-interacting protein 2
UniProt Protein Function:MAPK8IP2: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Belongs to the JIP scaffold family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protein kinase, regulatory subunit; Activator

Chromosomal Location of Human Ortholog: 22q13.33

Cellular Component: protein complex; cell soma; cytoplasm

Molecular Function:MAP-kinase scaffold activity; protein binding; kinesin binding; beta-amyloid binding; protein complex binding; structural molecule activity; protein kinase binding; protein kinase activator activity

Biological Process: nonassociative learning; regulation of synaptic transmission, glutamatergic; behavioral fear response; dendrite morphogenesis; MAPKKK cascade; mating behavior; signal complex assembly; social behavior; regulation of JNK cascade; positive regulation of stress-activated MAPK cascade; positive regulation of protein kinase activity; JNK cascade; regulation of receptor activity; regulation of excitatory postsynaptic membrane potential

NCBI Summary:The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q13387
NCBI GenInfo Identifier:6912492
NCBI Gene ID:23542
NCBI Accession:NP_036456.1
UniProt Secondary Accession:Q13387,Q96G62, Q99771, Q9NZ59, Q9UKQ4,
UniProt Related Accession:Q13387
Molecular Weight:87,975 Da
NCBI Full Name:C-Jun-amino-terminal kinase-interacting protein 2 isoform 1
NCBI Synonym Full Names:mitogen-activated protein kinase 8 interacting protein 2
NCBI Official Symbol:MAPK8IP2  
NCBI Official Synonym Symbols:IB2; JIP2; PRKM8IPL  
NCBI Protein Information:C-Jun-amino-terminal kinase-interacting protein 2; IB-2; islet-brain 2; JNK-interacting protein 2; homologous to mouse JIP-1; JNK MAP kinase scaffold protein 2; JNK MAP kinase scaffold protein JIP2
UniProt Protein Name:C-Jun-amino-terminal kinase-interacting protein 2
UniProt Synonym Protein Names:Islet-brain-2; IB-2; JNK MAP kinase scaffold protein 2; Mitogen-activated protein kinase 8-interacting protein 2
UniProt Gene Name:MAPK8IP2  
UniProt Entry Name:JIP2_HUMAN

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