ERK5 Rabbit Polyclonal Antibody (CAB2111)
- SKU:
- CAB2111
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
Product Name: | ERK5 Rabbit Polyclonal Antibody |
SKU: | CAB2111 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human ERK5 (NP_002740.2). |
Sequence: | MAEP LKEE DGED GSAE PPGP VKAE PAHT AASV AAKN LALL KARS FDVT FDVG DEYE IIET IGNG AYGV VSSA RRRL TGQQ VAIK KIPN AFDV VTNA KRTL RELK ILKH FKHD NIIA IKDI LRPT VPYG EFKS VYVV LDLM ESDL HQII HSSQ PLTL EHVR YFLY QLLR GLKY MHSA QVIH RDLK PSNL LVNE NCEL KIGD FGMA RGLC TSPA EHQY FMTE YVAT RWYR APEL MLSL HEYT QAID LWSV GCIF GEML ARRQ LFPG KNYV HQLQ LIMM VLGT PSPA VIQA VGAE RVRA YIQS LPPR QPVP WE |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | BMK1; ERK4; ERK5; PRKM7 |
Positive Sample: | HeLa,293T,RD,C6,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, PML body. |
Calculated MW: | 88kDa |
Observed MW: | 115kDa |
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.
Purification Method: | Affinity purification |
Gene ID: | 5598 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |