The MAPK7 Polyclonal Antibody (CAB2111) is a valuable tool for researchers studying MAPK7, a member of the mitogen-activated protein kinase (MAPK) family that plays a crucial role in various cellular processes, including cell proliferation, differentiation, and apoptosis. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.MAPK7, also known as ERK5, is a key signaling molecule involved in cell growth and survival pathways. Its dysregulation has been linked to various diseases, including cancer, cardiovascular disorders, and neurodegenerative diseases.
By targeting MAPK7, researchers can gain insights into the mechanisms underlying these conditions and develop targeted therapies to treat them.This antibody enables the specific detection and analysis of MAPK7 protein in different cell types, making it ideal for studies in cell signaling, cancer biology, and drug development. Understanding the role of MAPK7 in disease pathology can lead to the identification of novel therapeutic targets and the development of more effective treatments.
Product Name:
ERK5 Rabbit Polyclonal Antibody
SKU:
CAB2111
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human ERK5 (NP_002740.2).
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.
Purification Method:
Affinity purification
Gene ID:
5598
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ERK5 Rabbit pAb (CAB2111) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
