The MAPK14 Polyclonal Antibody (CAB14401) is a powerful tool for researchers studying MAPK14, a key enzyme in the MAPK signaling pathway that plays a crucial role in various cellular processes including cell proliferation, differentiation, and apoptosis. This antibody, generated in rabbits, exhibits high specificity and sensitivity when detecting MAPK14 protein in human samples, making it an excellent choice for Western blotting applications.MAPK14, also known as p38 MAPK, is involved in regulating inflammatory responses, stress signaling, and cell survival pathways. Dysregulation of MAPK14 activity has been linked to numerous diseases, including cancer, inflammatory disorders, and neurodegenerative conditions.
By targeting MAPK14 with this antibody, researchers can gain insights into its function and potential therapeutic applications in these disease contexts.The MAPK14 Polyclonal Antibody is an invaluable tool for investigating the role of MAPK14 in cellular signaling pathways and disease pathogenesis. Its specificity, sensitivity, and reliability make it an essential component for studies in molecular biology, pharmacology, and drug development. Researchers can confidently use this antibody to explore the intricate mechanisms of MAPK14 signaling and its implications in health and disease.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Purification Method:
Affinity purification
Gene ID:
1432
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using p38 MAPK Rabbit pAb (CAB14401) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
