The MAP4K5 Polyclonal Antibody (CAB15139) is a valuable tool for researchers studying the protein MAP4K5, a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family involved in various cellular processes including cell proliferation and differentiation. This antibody, generated in rabbits, exhibits high specificity and reactivity with human samples, making it suitable for Western blot applications to detect the presence of MAP4K5 in different cell types.MAP4K5, also known as apoptosis signal-regulating kinase 1, plays a crucial role in signaling pathways that regulate cell survival and apoptosis in response to external stimuli. Dysregulation of MAP4K5 has been implicated in diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases, highlighting its potential as a therapeutic target.
By targeting MAP4K5, researchers aim to gain insights into the mechanisms underlying these diseases and develop novel treatment strategies.The MAP4K5 Polyclonal Antibody (CAB15139) offers researchers a reliable tool to study the function and expression of MAP4K5 in a variety of biological contexts, paving the way for advancements in drug discovery and personalized medicine. Its versatility and specificity make it an essential reagent for investigations into the role of MAP4K5 in health and disease.
Product Name:
MAP4K5 Rabbit Polyclonal Antibody
SKU:
CAB15139
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 300-480 of human MAP4K5 (NP_006566.2).
This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
11183
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of U2OS cells using MAP4K5 antibody (CAB15139) at dilution of 1:100. Blue: DAPI for nuclear staining.
