The MAP4K2 Polyclonal Antibody (CAB17524) is a valuable tool for researchers studying the MAP4K2 protein, which plays a key role in cellular signaling pathways involved in immune regulation and inflammatory responses. This rabbit-derived antibody has been extensively validated for use in Western blot applications and is highly reactive with human samples, ensuring reliable and accurate results.MAP4K2, also known as mitogen-activated protein kinase kinase kinase kinase 2, is a critical regulator of various cellular processes, including cell growth, proliferation, and survival. Dysregulation of MAP4K2 activity has been implicated in several diseases, including cancer, inflammatory disorders, and autoimmune conditions.
The ability to detect and analyze MAP4K2 protein levels in different cell types makes this antibody an essential tool for researchers investigating the role of MAP4K2 in disease pathogenesis.By understanding the function of MAP4K2, researchers can uncover new therapeutic targets for the treatment of diseases characterized by dysregulated immune responses and inflammation. The MAP4K2 Polyclonal Antibody (CAB17524) provides a reliable and sensitive means of studying this important protein, leading to advancements in immunology and cancer research.
Product Name:
MAP4K2 Rabbit Polyclonal Antibody
SKU:
CAB17524
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 551-820 of human MAP4K2 (NP_004570.2).
The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5871
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MAP4K2 Rabbit pAb (CAB17524) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
