The MAP4K1 Polyclonal Antibody (PAC021916) is a valuable research tool for studying MAP4K1, a protein kinase involved in various cellular processes, including cell survival, proliferation, and differentiation. This antibody, generated in rabbits, shows high specificity and sensitivity towards human MAP4K1 protein in Western blot applications, allowing for accurate detection and analysis in different cell types.MAP4K1, also known as hematopoietic progenitor kinase 1 (HPK1), is a key regulator of immune responses and plays a crucial role in signaling pathways related to inflammation and immune cell activation. Its dysregulation has been implicated in various diseases, including cancer and autoimmune disorders, making it a promising target for therapeutic interventions.
Research on MAP4K1 can provide insights into its role in disease pathogenesis and help in the development of targeted therapies for these conditions.Overall, the MAP4K1 Polyclonal Antibody (PAC021916) is a reliable tool for researchers interested in studying the functions and mechanisms of MAP4K1 in immunology, cancer biology, and other disease-related fields. Its high specificity and reactivity make it a valuable asset for advancing our understanding of cellular signaling pathways and potential therapeutic targets.
Antibody Name:
MAP4K1 Antibody (PACO21916)
Antibody SKU:
PACO21916
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human MEKKK 1.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HepG2 cells, using MEKKK 1 antibody.
Background:
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
HPK1: a protein kinase of the STE20 family. Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. May play a role in hematopoietic lineage decisions and growth regulation. Positively regulated by PGE2 and a negative regulator of PGE2-induced FOS gene transcription. Protein type: Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; STE group; STE20 family; KHS subfamilyChromosomal Location of Human Ortholog: 19q13.1-q13.4Cellular Component: cytoplasm; membraneMolecular Function: ATP binding; MAP kinase kinase kinase kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activityBiological Process: activation of JNK activity; activation of MAPKKK activity; cell proliferation; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; response to stress
