The MAP4K1 Antibody (PAC018445) is a valuable tool for researchers studying the MAP4K1 protein, a key regulator of cell signaling pathways involved in various cellular processes. This polyclonal antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for applications such as Western blot analysis.MAP4K1, also known as mitogen-activated protein kinase kinase kinase kinase 1, plays a critical role in cell proliferation, survival, and migration by activating downstream signaling cascades. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disorders, and immune-related conditions.
By targeting MAP4K1 with this antibody, researchers can investigate its function and potential therapeutic implications in these diseases.With its validated reactivity and reliability in detecting MAP4K1 protein expression in different cell types, this antibody is a valuable asset for studies in molecular biology, oncology, and signal transduction research. By understanding the role of MAP4K1 in cellular signaling pathways, researchers can advance our understanding of disease mechanisms and potentially identify novel therapeutic targets.
Antibody Name:
MAP4K1 Antibody (PACO18445)
Antibody SKU:
PACO18445
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human MAP4K1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO18445(MAP4K1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18445(MAP4K1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily. It plays a role in the response to environmental stress and hematopoietic lineage decisions and growth regulation. Appears to act upstream of the JUN N-terminal pathway.
Synonyms:
mitogen-activated protein kinase kinase kinase kinase 1
UniProt Protein Function:
HPK1: a protein kinase of the STE20 family. Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. May play a role in hematopoietic lineage decisions and growth regulation. Positively regulated by PGE2 and a negative regulator of PGE2-induced FOS gene transcription. Protein type: Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; STE group; STE20 family; KHS subfamilyChromosomal Location of Human Ortholog: 19q13.1-q13.4Cellular Component: cytoplasm; membraneMolecular Function: ATP binding; MAP kinase kinase kinase kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activityBiological Process: activation of JNK activity; activation of MAPKKK activity; cell proliferation; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; response to stress
