The MAP4K1 Polyclonal Antibody (PACO18444) is a valuable tool for researchers studying MAP4K1, a protein kinase involved in various cellular processes, including cell proliferation, migration, and survival. This antibody, produced in rabbits, has been validated for use in Western blot applications and demonstrates high reactivity with human samples.MAP4K1, also known as hematopoietic progenitor kinase 1 (HPK1), plays a crucial role in signaling pathways that regulate immune responses and inflammation. By targeting MAP4K1, researchers can investigate its role in diseases such as cancer, autoimmune disorders, and inflammatory conditions.
Understanding the function of MAP4K1 can lead to the development of targeted therapies for these diseases by modulating its activity.Overall, the MAP4K1 Polyclonal Antibody is an essential tool for researchers studying MAP4K1 and its implications in various disease processes. Its high reactivity and specificity make it ideal for use in immunology and cancer research studies.
Antibody Name:
MAP4K1 Antibody (PACO18444)
Antibody SKU:
PACO18444
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human MAP4K1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18444(MAP4K1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18444(MAP4K1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily. It plays a role in the response to environmental stress and hematopoietic lineage decisions and growth regulation. Appears to act upstream of the JUN N-terminal pathway.
Synonyms:
mitogen-activated protein kinase kinase kinase kinase 1
UniProt Protein Function:
HPK1: a protein kinase of the STE20 family. Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. May play a role in hematopoietic lineage decisions and growth regulation. Positively regulated by PGE2 and a negative regulator of PGE2-induced FOS gene transcription. Protein type: Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; STE group; STE20 family; KHS subfamilyChromosomal Location of Human Ortholog: 19q13.1-q13.4Cellular Component: cytoplasm; membraneMolecular Function: ATP binding; MAP kinase kinase kinase kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activityBiological Process: activation of JNK activity; activation of MAPKKK activity; cell proliferation; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; response to stress
