The MAP3K9/MAP3K10 Antibody (PACO04336) is a valuable tool for research into the MAP3K9 and MAP3K10 proteins, which play key roles in signaling pathways related to cell differentiation, proliferation, and survival. This polyclonal antibody, generated using rabbits, has high specificity for human samples and is validated for use in Western blot applications.MAP3K9 and MAP3K10 are members of the mitogen-activated protein kinase kinase kinase (MAP3K) family, which are essential components of cellular pathways involved in the response to various stimuli, including stress, cytokines, and growth factors. Understanding the function of these proteins is crucial for unraveling the complexities of cell signaling and their potential roles in diseases such as cancer, neurodegenerative disorders, and immune-related conditions.
By targeting MAP3K9 and MAP3K10, researchers can gain insight into the mechanisms underlying these diseases and explore potential therapeutic strategies to manipulate these pathways for therapeutic benefit. The PACO04336 antibody enables precise detection and analysis of these proteins in various cell types, making it an invaluable tool for studies in cancer biology, neurology, and immunology.
Antibody Name:
MAP3K9/MAP3K10 Antibody
Antibody SKU:
PACO04336
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from human MLK1/2 around the non-phosphorylation site of T312/266.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
MAP3K9; MLK1; PRKE1; Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1; MAP3K10; MLK2; MST; Mitogen-activated protein kinase kinase kinase 10; Mixed lineage kinase 2; Protein kinase MST
UniProt Protein Function:
MLK1: a TKL kinase of the MLK family. A dual leucine zipper kinase. Expressed in neuronal cells and may act between Rac1/Cdc42 and MKK4 and -7 in death signaling. Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.25; Protein kinase, TKL; TKL group; MLK family; MLK subfamilyChromosomal Location of Human Ortholog: 14q24.2Molecular Function: JUN kinase kinase kinase activity; protein binding; protein homodimerization activity; protein serine/threonine kinase activityBiological Process: activation of JNK activity; protein amino acid autophosphorylation; protein amino acid phosphorylation
