MAP3K8 Rabbit Polyclonal Antibody (CAB15623)
- SKU:
- CAB15623
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | MAP3K8 Rabbit Polyclonal Antibody |
SKU: | CAB15623 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MAP3K8 (NP_005195.2). |
Sequence: | MEYM STGS DNKE EIDL LIKH LNVS DVID IMEN LYAS EEPA VYEP SLMT MCQD SNQN DERS KSLL LSGQ EVPW LSSV RYGT VEDL LAFA NHIS NTAK HFYG |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:100 - 1:500 |
Synonyms: | COT; EST; ESTF; TPL2; AURA2; MEKK8; Tpl-2; c-COT; MAP3K8 |
Positive Sample: | 293T |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol |
Calculated MW: | 53kDa |
Observed MW: | 52kDa |
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.
Purification Method: | Affinity purification |
Gene ID: | 1326 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |