TAK1 Rabbit Polyclonal Antibody (CAB12022)
- SKU:
- CAB12022
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | TAK1 Rabbit Polyclonal Antibody |
SKU: | CAB12022 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-325 of human TAK1 (NP_663304.1). |
Sequence: | GSLY NVLH GAEP LPYY TAAH AMSW CLQC SQGV AYLH SMQP KALI HRDL KPPN LLLV AGGT VLKI CDFG TACD IQTH MTNN KGSA AWMA PEVF EGSN YSEK CDVF SWGI ILWE VITR RKPF DEIG GPAF RIMW AVHN GTRP PLIK NLPK PIES LMTR CWSK DPSQ RPSM EEIV KIMT HLMR YFPG ADEP LQYP CQYS DEGQ SNSA TSTG SFMD IAST |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | CSCF; FMD2; TAK1; MEKK7; TGF1a |
Positive Sample: | HeLa,COS-7,Mouse heart,Rat heart,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Cytoplasmic side, Peripheral membrane protein. |
Calculated MW: | 67kDa |
Observed MW: | 67kDa/75kDa |
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Purification Method: | Affinity purification |
Gene ID: | 6885 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |