The MAP3K6 Polyclonal Antibody (PACO21709) is a valuable tool for researchers studying the MAP3K6 protein, which is involved in various cellular processes including cell growth, differentiation, and apoptosis. This antibody is raised in rabbits and has been validated for use in Western blot applications with human samples.MAP3K6, also known as mitogen-activated protein kinase kinase kinase 6, is a key player in signaling pathways that regulate cell behavior and responses to external stimuli. By detecting and analyzing MAP3K6 expression in different cell types, this antibody allows for a better understanding of the protein's role in cell signaling and potential implications in diseases such as cancer and inflammatory disorders.
The MAP3K6 Polyclonal Antibody is a valuable tool for researchers interested in unraveling the molecular mechanisms underlying cellular processes and diseases influenced by MAP3K6 activity. Its high reactivity and specificity make it an ideal choice for studies in biochemistry, cell biology, and cancer research.
Antibody Name:
MAP3K6 Antibody (PACO21709)
Antibody SKU:
PACO21709
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:50-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human MAP3K6.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using MAP3K6 antibody.
Background:
Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. Gregory S.G., Nature 441:315-321(2006).
MEKK6: a member of the STE11 protein kinase family. Activates JNK, but not ERK or p38. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Protein type: Protein kinase, STE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.25; STE group; STE11 familyChromosomal Location of Human Ortholog: 1p36.11Molecular Function: ATP binding; magnesium ion binding; MAP kinase kinase kinase activityBiological Process: activation of JNK activity; protein amino acid phosphorylation; signal transduction
UniProt Protein Details:
NCBI Summary:
This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
