UniProt Protein Function: | MEKK6: a member of the STE11 protein kinase family. Activates JNK, but not ERK or p38. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Protein type: Protein kinase, STE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.25; STE group; STE11 familyChromosomal Location of Human Ortholog: 1p36.11Molecular Function: ATP binding; magnesium ion binding; MAP kinase kinase kinase activityBiological Process: activation of JNK activity; protein amino acid phosphorylation; signal transduction |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
UniProt Code: | O95382 |
NCBI GenInfo Identifier: | 262527573 |
NCBI Gene ID: | 9064 |
NCBI Accession: | O95382.3 |
UniProt Secondary Accession: | O95382,Q59HF4, Q5SSD4, Q75PK3, Q96B75, A2ACE8, A2VDG4 A2VDG5 |
UniProt Related Accession: | O95382, JE0363 |
Molecular Weight: | 141,648 Da |
NCBI Full Name: | Mitogen-activated protein kinase kinase kinase 6 |
NCBI Synonym Full Names: | mitogen-activated protein kinase kinase kinase 6 |
NCBI Official Symbol: | MAP3K6Â Â |
NCBI Official Synonym Symbols: | ASK2; MEKK6; MAPKKK6Â Â |
NCBI Protein Information: | mitogen-activated protein kinase kinase kinase 6 |
UniProt Protein Name: | Mitogen-activated protein kinase kinase kinase 6 |
UniProt Synonym Protein Names: | Apoptosis signal-regulating kinase 2 |
Protein Family: | Mitogen-activated protein kinase kinase kinase |
UniProt Gene Name: | MAP3K6Â Â |
UniProt Entry Name: | M3K6_HUMAN |