MAP3K5 Rabbit Polyclonal Antibody (CAB12458)
- SKU:
- CAB12458
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
Product Name: | MAP3K5 Rabbit Polyclonal Antibody |
SKU: | CAB12458 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-161 of human MAP3K5 (NP_005914.1). |
Sequence: | MSTE ADEG ITFS VPPF APSG FCTI PEGG ICRR GGAA AVGE GEEH QLPP PPPG SFWN VESA AAPG IGCP AATS SSSA TRGR GSSV GGGS RRTT VAYV INEA SQGQ LVVA ESEA LQSL REAC ETVG ATLE TLHF GKLD FGET TVLD RFYN ADIA VVEM SDAF R |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | ASK1; MEKK5; MAPKKK5; MAP3K5 |
Positive Sample: | HeLa,A-549,BxPC-3,A-431,Mouse lung,Mouse brain,Mouse heart,Rat lung,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Endoplasmic reticulum. |
Calculated MW: | 155kDa |
Observed MW: | 160kDa |
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.
Purification Method: | Affinity purification |
Gene ID: | 4217 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |