MAP3K5 Rabbit Polyclonal Antibody (CAB0283)
- SKU:
- CAB0283
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
Product Name: | MAP3K5 Rabbit Polyclonal Antibody |
SKU: | CAB0283 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1175-1374 of human MAP3K5 (NP_005914.1). |
Sequence: | RPHF SLAS ESDT ADQE DLDV EDDH EEQP SNQT VRRP QAVI EDAV ATSG VSTL SSTV SHDS QSAH RSLN VQLG RMKI ETNR LLEE LVRK EKEL QALL HRAI EEKD QEIK HLKL KSQP IEIP ELPV FHLN SSGT NTED SELT DWLR VNGA DEDT ISRF LAED YTLL DVLY YVTR DDLK CLRL RGGM LCTL WKAI IDFR NKQT |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | ASK1; MEKK5; MAPKKK5; MAP3K5 |
Positive Sample: | HL-60,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Endoplasmic reticulum. |
Calculated MW: | 155kDa |
Observed MW: | 155kDa |
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.
Purification Method: | Affinity purification |
Gene ID: | 4217 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |