The MAP3K14 Polyclonal Antibody (CAB11585) is a valuable tool for researchers studying the mitogen-activated protein kinase kinase kinase 14 (MAP3K14) protein, also known as NIK. NIK is a key regulator of the NF-κB pathway, playing a crucial role in immune and inflammatory responses.This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By specifically binding to the MAP3K14 protein, researchers can accurately detect and analyze its expression in various cell types.
This makes the antibody ideal for studies in immunology, inflammation, and cancer research.Understanding the function of MAP3K14 is essential for elucidating its role in diseases such as cancer, autoimmune disorders, and inflammatory conditions. By targeting this protein, researchers can develop potential therapies that modulate the NF-κB pathway, providing new avenues for the treatment of these complex diseases.
Product Name:
MAP3K14 Rabbit Polyclonal Antibody
SKU:
CAB11585
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 330-662 of human MAP3K14 (NP_003945.2).
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
Purification Method:
Affinity purification
Gene ID:
9020
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat lung, using MAP3K14 antibody (CAB11585) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
