The MAP3K11 Polyclonal Antibody (CAB16242) is a valuable tool for researchers studying the MAP3K11 protein, which plays a crucial role in cell signaling pathways related to inflammation, immune response, and cancer development. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the MAP3K11 protein, the antibody enables detection and analysis in various cell types, making it ideal for studies in immunology and cancer research.MAP3K11, also known as mixed-lineage kinase-3 (MLK3), is a key player in signaling cascades that regulate cell growth, survival, and differentiation.
Dysregulation of MAP3K11 has been implicated in various diseases, including cancer, inflammatory disorders, and neurodegenerative conditions. Understanding the role of MAP3K11 is crucial for developing targeted therapies that can modulate its activity in disease settings.Overall, the MAP3K11 Polyclonal Antibody is a valuable tool for researchers looking to unravel the complex signaling pathways involving MAP3K11 and its impact on disease development and progression. Its high specificity and sensitivity make it a reliable choice for studies aimed at elucidating the functions of this important protein.
Product Name:
MAP3K11 Rabbit Polyclonal Antibody
SKU:
CAB16242
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 140-260 of human MAP3K11 (NP_002410.1).
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.
Purification Method:
Affinity purification
Gene ID:
4296
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse thymus, using MAP3K11 Rabbit pAb (CAB16242) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
