The MAP3K10 Polyclonal Antibody (PACO10365) is a valuable research tool for studying MAP3K10, a protein kinase involved in cell signaling pathways related to inflammation and immune response. This antibody was generated in rabbits and is highly specific to human samples, making it a reliable tool for various research applications.MAP3K10, also known as MEKK10, is a key regulator of MAP kinase cascades that play a role in cell growth, differentiation, and apoptosis. It is involved in mediating cellular responses to external stimuli and regulates gene expression in immune cells. The MAP3K10 antibody allows for the detection and analysis of MAP3K10 protein levels in different cell types, facilitating research in immunology, cancer biology, and inflammatory diseases.
By targeting MAP3K10, researchers can gain insights into the molecular mechanisms underlying immune system function and inflammatory processes. Understanding the role of MAP3K10 in disease pathways may lead to the development of novel therapeutic strategies for conditions such as cancer, autoimmune disorders, and chronic inflammation. The MAP3K10 Polyclonal Antibody is a valuable tool for advancing scientific knowledge and potentially identifying new treatment approaches.
mitogen-activated protein kinase kinase kinase 10;MAP3K10;MLK2;MST ;
UniProt Protein Function:
MLK2: a TKL kinase of the MLK family. A dual leucine zipper kinase. Phosphorylates and activates JNK and SEK1. Interacts with PAK and NCK. May be involved in nerve growth factor-induced neuronal apoptosis.Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.25; Protein kinase, TKL; TKL group; MLK family; MLK subfamilyChromosomal Location of Human Ortholog: 19q13.2Cellular Component: cytoplasmMolecular Function: ATP binding; bHLH transcription factor binding; JUN kinase kinase kinase activity; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; transcription corepressor activityBiological Process: activation of JNK activity; activation of JNKK activity; apoptosis; JNK cascade; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of apoptosis; positive regulation of JNK activity; positive regulation of JNK cascade; protein amino acid autophosphorylation; signal transduction; smoothened signaling pathway
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]
