Similarly, the MAP3K10 Polyclonal Antibody (PACO04337) is a valuable tool for researchers studying the MAP3K10 protein, a member of the MAP kinase kinase kinase family involved in various cellular processes, including cell growth, differentiation, and apoptosis. This antibody, also raised in rabbits, has been rigorously validated for specificity and sensitivity in Western blot applications, allowing for accurate detection of MAP3K10 in human samples.MAP3K10 is known to play a pivotal role in signal transduction pathways that regulate cell proliferation and survival, making it a potential target for therapeutic interventions in cancer and other diseases.
Studies have shown that dysregulation of MAP3K10 activity is associated with various cancers, making it a promising candidate for further investigation in oncology research.Overall, the MAP3K10 Polyclonal Antibody offers researchers a reliable tool for investigating the function and expression of MAP3K10 in a variety of cell types, providing valuable insights into its role in cellular signaling pathways and potential implications for disease progression and treatment.
Antibody Name:
MAP3K10 Antibody
Antibody SKU:
PACO04337
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the Internal region of human MLK2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
MAP3K10; MLK2; MST; Mitogen-activated protein kinase kinase kinase 10; Mixed lineage kinase 2; Protein kinase MST
UniProt Protein Function:
MLK2: a TKL kinase of the MLK family. A dual leucine zipper kinase. Phosphorylates and activates JNK and SEK1. Interacts with PAK and NCK. May be involved in nerve growth factor-induced neuronal apoptosis.Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.25; Protein kinase, TKL; TKL group; MLK family; MLK subfamilyChromosomal Location of Human Ortholog: 19q13.2Cellular Component: cytoplasmMolecular Function: ATP binding; bHLH transcription factor binding; JUN kinase kinase kinase activity; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; transcription corepressor activityBiological Process: activation of JNK activity; activation of JNKK activity; apoptosis; JNK cascade; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of apoptosis; positive regulation of JNK activity; positive regulation of JNK cascade; protein amino acid autophosphorylation; signal transduction; smoothened signaling pathway
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]
