MEK5 Rabbit Polyclonal Antibody (CAB6953)
- SKU:
- CAB6953
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | MEK5 Rabbit Polyclonal Antibody |
SKU: | CAB6953 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human MEK5 (NP_660143.1). |
Sequence: | MLWL ALGP FPAM ENQV LVIR IKIP NSGA VDWT VHSG PQLL FRDV LDVI GQVL PEAT TTAF EYED EDGD RITV RSDE EMKA MLSY YYST VMEQ QVNG QLIE PLQI FPRA CKPP GERN IHGL KVNT RAGP SQHS SPAV SDSL PSNS LKKS SAEL KKIL ANGQ MNEQ DIRY RDTL GHGN GGTV YKAY HVPS GK |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:100 |
Synonyms: | MEK5; MAPKK5; PRKMK5; HsT17454 |
Positive Sample: | NCI-H460,BT-474,Mouse liver,Rat liver,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, nucleus, spindle |
Calculated MW: | 50kDa |
Observed MW: | 50kDa |
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
Purification Method: | Affinity purification |
Gene ID: | 5607 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |