The MAP2K5 Polyclonal Antibody (CAB6953) is a valuable tool for researchers studying the MAP2K5 protein, a key player in various signaling pathways involved in cell growth, differentiation, and apoptosis. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By binding to the MAP2K5 protein, researchers can easily detect and analyze its expression in different cell types, making it ideal for studies in cellular signaling and cancer research.
MAP2K5, also known as MEK5, is a crucial component of the MAPK signaling pathway and is involved in regulating various cellular processes such as proliferation and differentiation. Dysregulation of MAP2K5 has been implicated in various diseases, including cancer, cardiovascular disorders, and neurodegenerative diseases. By studying the function of MAP2K5, researchers can gain insights into the underlying mechanisms of these diseases and potentially identify new therapeutic targets for intervention.
Product Name:
MEK5 Rabbit Polyclonal Antibody
SKU:
CAB6953
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human MEK5 (NP_660143.1).
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
5607
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MEK5 Rabbit pAb (CAB6953) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
