The MEK5 Rabbit Monoclonal Antibody is a powerful tool for researchers studying the MEK5 protein, a key player in cell signaling pathways involved in cell growth and differentiation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications.MEK5, a member of the MAP kinase kinase family, is primarily involved in the activation of the ERK5 pathway, which regulates gene expression in response to various stimuli. Dysregulation of the MEK5-ERK5 pathway has been linked to various diseases, including cancer, cardiovascular disorders, and neurodegenerative diseases.
By targeting MEK5 with this antibody, researchers can investigate the role of this protein in different cellular processes and disease states.By using the MEK5 Rabbit Monoclonal Antibody, researchers can gain valuable insights into the function and regulation of the MEK5 protein, opening up new possibilities for therapeutic interventions targeting this pathway in disease treatment and management. This antibody is a valuable tool for research in cell biology, cancer biology, and drug discovery.
Product Name:
MEK5 Rabbit Monoclonal Antibody
SKU:
CAB12457
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human MEK5 (Q13163).
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
5607
Clone Number:
ARC0711
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of RD cells, using MEK5 Rabbit mAb (CAB12457) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
