The MAP2K4 Polyclonal Antibody is a valuable tool for researchers studying the MAP2K4 protein, a key regulator of cellular signaling pathways involved in various biological processes. This antibody, generated in rabbits, demonstrates high reactivity with human samples and is specifically validated for use in Western blot applications. It binds to the MAP2K4 protein, allowing for precise detection and analysis in different cell types, making it an ideal choice for studies in cell signaling, cancer biology, and drug development.MAP2K4 is a crucial mediator of signal transduction pathways that regulate cell growth, differentiation, and apoptosis.
Dysregulation of MAP2K4 activity has been implicated in various diseases, including cancer and neurological disorders. Research on the functions and mechanisms of MAP2K4 is essential for understanding its role in disease pathogenesis and for identifying potential therapeutic targets. The MAP2K4 Polyclonal Antibody provides researchers with a reliable tool to investigate the expression and activity of MAP2K4 in different experimental systems, contributing to advancements in biomedical research and drug discovery.
Product Name:
MAP2K4 Polyclonal Antibody
SKU:
CAB21597
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 300-399 of human MAP2K4 (NP_003001.1).
This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
6416
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from A-549 cells, using MAP2K4 Rabbit pAb (CAB21597) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
