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Map2k4 Antibody (PACO28138)

SKU:
PACO28138
Product Type:
Antibody
Reactivity:
Mouse
Rat
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$407
Frequently bought together:

Description

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Map2k4 Antibody (PACO28138)

The MAP2K4 Polyclonal Antibody (PACO28138) is a valuable tool for researchers studying the MAP2K4 protein, a key player in cell signaling pathways that regulate processes such as cell growth, differentiation, and response to stress. This antibody is produced in rabbits and has been extensively validated for use in Western blot applications, where it specifically binds to the MAP2K4 protein.MAP2K4, also known as mitogen-activated protein kinase kinase 4, is involved in various cellular functions, including cell proliferation and apoptosis.

Dysregulation of MAP2K4 has been linked to diseases like cancer, making it an attractive target for further investigation in cancer research. By understanding the role of MAP2K4 in signaling pathways, researchers can potentially uncover new therapeutic targets for cancer treatment.Overall, the MAP2K4 Polyclonal Antibody (PACO28138) offers a reliable tool for researchers interested in studying the functions and mechanisms of MAP2K4 in different cellular processes, with potential applications in cancer biology and drug discovery.

Antibody Name:Map2k4 Antibody (PACO28138)
Antibody SKU:PACO28138
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:Mouse, Rat, Human
Immunogen:Recombinant Mouse Dual specificity mitogen-activated protein kinase kinase 4 protein (2-397AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern Blot
Positive WB detected in: RAW264.7 whole cell lysate, HepG2 whole cell lysate, Rat liver tissue, Mouse brain tissue
All lanes: Map2k4 antibody at 3.2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 45 kDa
Observed band size: 45 kDa
.
Background:Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
Synonyms:Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1), Map2k4, Jnkk1 Mek4 Mkk4 Prkmk4 Sek1 Serk1 Skk1
UniProt Protein Function:MKK4: dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38 but not ERK1 or -2. Mediates cellular responses to various cellular stresses and inflammatory cytokines. Phosphorylation by Akt inhibits MKK4 and suppresses stress-activated signal transduction.Protein type: Protein kinase, dual-specificity (non-receptor); Protein kinase, STE; EC 2.7.12.2; Kinase, protein; STE group; STE7 familyCellular Component: axon; cytoplasm; cytosol; dendrite cytoplasm; nucleus; perikaryonMolecular Function: ATP binding; JUN kinase kinase activity; MAP kinase kinase activity; mitogen-activated protein kinase kinase kinase binding; protein binding; receptor signaling protein serine/threonine kinase activityBiological Process: activation of JNK activity; JNK cascade; MAPKKK cascade; positive regulation of apoptosis; positive regulation of DNA replication; positive regulation of neuron apoptosis; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of protein amino acid phosphorylation; protein amino acid phosphorylation; response to wounding
UniProt Protein Details:
NCBI Summary:
UniProt Code:P47809
NCBI GenInfo Identifier:2507202
NCBI Gene ID:26398
NCBI Accession:P47809.2
UniProt Secondary Accession:P47809
UniProt Related Accession:P47809
Molecular Weight:44,114 Da
NCBI Full Name:Dual specificity mitogen-activated protein kinase kinase 4
NCBI Synonym Full Names:mitogen-activated protein kinase kinase 4
NCBI Official Symbol:Map2k4  
NCBI Official Synonym Symbols:MEK4; MKK4; Sek1; JNKK1; Serk1; PRKMK4  
NCBI Protein Information:dual specificity mitogen-activated protein kinase kinase 4
UniProt Protein Name:Dual specificity mitogen-activated protein kinase kinase 4
UniProt Synonym Protein Names:C-JUN N-terminal kinase kinase 1; JNK kinase 1; JNKK 1; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1
Protein Family:Dual specificity mitogen-activated protein kinase kinase
UniProt Gene Name:Map2k4  
UniProt Entry Name:MP2K4_MOUSE
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