The MAP2K3 Polyclonal Antibody (CAB7718) is a valuable tool for researchers studying the MAP2K3 protein, a key player in cell signaling pathways and the regulation of cell growth and differentiation. This antibody, generated in rabbits, exhibits high specificity and reactivity towards human samples, making it ideal for use in Western blot applications.MAP2K3, also known as dual specificity mitogen-activated protein kinase kinase 3, is involved in the MAPK signaling pathway and plays a crucial role in cell proliferation, differentiation, and apoptosis. Dysregulation of MAP2K3 has been linked to various diseases, including cancer, making it a potential target for therapeutic interventions.
By using the MAP2K3 Polyclonal Antibody, researchers can detect and analyze the expression levels of MAP2K3 in different cell types, allowing for a better understanding of its function in both physiological and pathological conditions. This antibody is a valuable resource for studies in cancer biology, cell signaling, and drug discovery, providing insights that may lead to new therapeutic strategies for treating MAP2K3-associated diseases.
Product Name:
MEK3 Rabbit Polyclonal Antibody
SKU:
CAB7718
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human MEK3 (NP_659731.1).
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.
Purification Method:
Affinity purification
Gene ID:
5606
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MEK3 Rabbit pAb (CAB7718) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
