The MAP2K2 Polyclonal Antibody (CAB0253) is a valuable tool for researchers studying the MAP2K2 protein, a key player in the MAPK signaling pathway involved in cell growth, differentiation, and survival. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to MAP2K2, researchers can accurately detect and analyze this important protein in a variety of cell types, making it an ideal choice for studies in molecular biology and cancer research.MAP2K2, also known as MEK2, is a critical mediator of cellular signaling pathways that control processes such as cell proliferation and survival.
Dysregulation of MAP2K2 activity has been implicated in various diseases, including cancer, making it a promising target for therapeutic interventions. Understanding the function of MAP2K2 is essential for developing targeted treatments that can potentially disrupt cancer cell growth and progression.With its high specificity and reliability, the MAP2K2 Polyclonal Antibody (CAB0253) offers researchers a valuable tool for investigating the role of MAP2K2 in cellular signaling pathways and disease development. Its versatility and accuracy make it a must-have for any laboratory conducting research in the fields of molecular biology and oncology.
Product Name:
MEK2 Rabbit Polyclonal Antibody
SKU:
CAB0253
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MEK2 (NP_109587.1).
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
5605
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of mouse brain, using MEK2 antibody (CAB0253).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
