The MAP2K1 Polyclonal Antibody (CAB0252) is a versatile tool for researchers studying the MAP2K1 protein, a key player in cellular signaling pathways that control cell growth, proliferation, and differentiation. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it an excellent choice for Western blot applications.MAP2K1, also known as MEK1, is a critical component of the MAPK/ERK pathway, which is involved in regulating various cellular processes such as cell cycle progression and survival.
Dysregulation of this pathway has been implicated in cancer development and progression, making MAP2K1 a potential target for therapeutic intervention.By detecting and analyzing MAP2K1 protein levels in different cell types, researchers can gain valuable insights into the role of this protein in normal cellular function and disease. This antibody is ideal for studies in cancer biology, cell signaling, and drug development, providing researchers with a powerful tool to advance their understanding of MAP2K1 biology.
Product Name:
MEK1 Rabbit Polyclonal Antibody
SKU:
CAB0252
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MEK1 (NP_002746.1).
Cytoplasm, Membrane, Nucleus, Peripheral membrane protein, centrosome, cytoskeleton, microtubule organizing center, spindle pole body.
Calculated MW:
43kDa
Observed MW:
46kDa
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
Purification Method:
Affinity purification
Gene ID:
5604
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MEK1 Rabbit pAb (CAB0252).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
