The MAP2 Polyclonal Antibody (CAB17409) is a valuable tool for researchers studying microtubule-associated protein 2 (MAP2), a protein essential for neuronal development and function. This antibody, produced in rabbits, is highly specific for detecting MAP2 in human samples and is validated for use in Western blot applications. By binding to MAP2, this antibody allows for precise detection and analysis of this important protein in various cell types, making it an ideal choice for studies in neuroscience and neurodegenerative diseases.
MAP2 is a key regulator of microtubule dynamics in neurons, playing a crucial role in neuronal morphology, axonal transport, and synaptic plasticity. Dysregulation of MAP2 has been implicated in neurodevelopmental disorders, neurodegenerative diseases, and psychiatric conditions. Investigating the function and expression of MAP2 is essential for understanding these disorders and developing potential therapeutic strategies to target them.
Product Name:
Map2 Rabbit Polyclonal Antibody
SKU:
CAB17409
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1510-1650 of human MAP2 (NP_002365.3).
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
4133
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using MAP2 Rabbit pAb (CAB17409) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
