The MAP2 Polyclonal Antibody (PACO18441) is a valuable tool for researchers studying microtubule-associated protein 2 (MAP2), a key player in neuronal development and plasticity. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in immunofluorescence and immunohistochemistry applications.MAP2 is essential for maintaining the structural integrity of neurons and regulating their function in the central nervous system. Studies have shown its involvement in neuronal differentiation, dendritic morphology, and synaptic plasticity, making it an important target for research in neurobiology and neuroscience.
By detecting and visualizing MAP2 protein expression in various cell types and tissue samples, the MAP2 Polyclonal Antibody enables researchers to better understand the mechanisms underlying neuronal development and function. This antibody is a valuable tool for investigating neurological disorders, neurodegenerative diseases, and brain injuries, ultimately contributing to the advancement of potential therapeutic strategies in these areas.
Antibody Name:
Map2 Antibody (PACO18441)
Antibody SKU:
PACO18441
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of mouse Map2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18441(Map2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18441(Map2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. It contains 3 Tau/MAP repeats. Phosphorylated at serine residues in K-X-G-S motifs by causing MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), detachment from microtubules, and their disassembly.
Synonyms:
microtubule-associated protein 2
UniProt Protein Function:
MAP2: a member of the microtubule-associated protein (MAP) family. Its exact function is unknown but MAPs appear to stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. Expressed at high levels in neural tissue and the prostate. Four alternatively spliced transcript variants have been reported.Protein type: Motility/polarity/chemotaxis; CytoskeletalCellular Component: microtubule; neuron projection; smooth endoplasmic reticulum; protein complex; rough endoplasmic reticulum; postsynaptic density; dendrite; microtubule associated complex; cytoskeleton; cell soma; cytoplasm; nucleolus; intracellular; dendritic shaftMolecular Function: tubulin binding; calmodulin binding; protein binding; microtubule binding; cytoskeletal regulatory protein bindingBiological Process: axonogenesis; dendrite development; microtubule bundle formation
