Map2 Antibody (PACO18440)
- SKU:
- PACO18440
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | Map2 Antibody (PACO18440) |
| Antibody SKU: | PACO18440 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:200-1:1000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of mouse Map2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18440(Map2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 8+10+12%SDS-PAGE, Lysate: 50 μg, Lane: Human lymphoma tissue, Primary antibody: PACO18440(Map2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 90 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18440(Map2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. It contains 3 Tau/MAP repeats. Phosphorylated at serine residues in K-X-G-S motifs by causing MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), detachment from microtubules, and their disassembly. |
| Synonyms: | microtubule-associated protein 2 |
| UniProt Protein Function: | MAP2: a member of the microtubule-associated protein (MAP) family. Its exact function is unknown but MAPs appear to stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. Expressed at high levels in neural tissue and the prostate. Four alternatively spliced transcript variants have been reported.Protein type: Motility/polarity/chemotaxis; CytoskeletalCellular Component: microtubule; neuron projection; smooth endoplasmic reticulum; protein complex; rough endoplasmic reticulum; postsynaptic density; dendrite; microtubule associated complex; cytoskeleton; cell soma; cytoplasm; nucleolus; intracellular; dendritic shaftMolecular Function: tubulin binding; calmodulin binding; protein binding; microtubule binding; cytoskeletal regulatory protein bindingBiological Process: axonogenesis; dendrite development; microtubule bundle formation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P20357 |
| NCBI GenInfo Identifier: | 341940935 |
| NCBI Gene ID: | 17756 |
| NCBI Accession: | P20357.2 |
| UniProt Secondary Accession: | P20357,E9QLE1 |
| UniProt Related Accession: | P20357 |
| Molecular Weight: | 61.2kDa |
| NCBI Full Name: | Microtubule-associated protein 2 |
| NCBI Synonym Full Names: | microtubule-associated protein 2 |
| NCBI Official Symbol: | Map2 |
| NCBI Official Synonym Symbols: | MAP-2; Mtap2; Mtap-2 |
| NCBI Protein Information: | microtubule-associated protein 2 |
| UniProt Protein Name: | Microtubule-associated protein 2 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Microtubule-associated protein |
| UniProt Gene Name: | Map2 |
| UniProt Entry Name: | MTAP2_MOUSE |
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