The MAP1LC3B Polyclonal Antibody (CAB7198) is a crucial tool for researchers studying autophagy, a cellular process essential for maintaining cellular homeostasis and responding to stress. This antibody, produced in rabbits, has high specificity and sensitivity for detecting the MAP1LC3B protein in human samples, making it ideal for use in Western blot and immunofluorescence applications.MAP1LC3B, a key component of the autophagy pathway, is involved in the formation of autophagosomes which engulf and degrade cellular components, including damaged organelles and proteins. Dysregulation of autophagy has been linked to various diseases, including neurodegenerative disorders, cancer, and metabolic conditions.
By using the MAP1LC3B Polyclonal Antibody, researchers can study the role of autophagy in these diseases and explore potential therapeutic strategies targeting this pathway.The versatility and reliability of the MAP1LC3B Polyclonal Antibody make it a valuable tool for immunology, cell biology, and cancer research. Its ability to specifically target MAP1LC3B protein in different experimental settings provides researchers with valuable insights into the intricate mechanisms of autophagy and its implications for human health and disease.
Product Name:
[KO Validated] LC3B Rabbit Polyclonal Antibody
SKU:
CAB7198
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LC3B (NP_073729.1).
The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component.
Purification Method:
Affinity purification
Gene ID:
81631
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KD Validated] LC3B Rabbit pAb (CAB7198) at 1:1000 dilution.NIH/3T3 and C6 cells were treated by Chloroquine (50 μM) at 37℃ for 20 hours.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
