The MAP1LC3A Polyclonal Antibody (CAB11438) is a pivotal tool for researchers studying autophagy and protein trafficking processes. This antibody, produced in rabbits, effectively recognizes the MAP1LC3A protein, a key player in autophagosome formation and maturation. Validated for use in Western blot applications, this antibody provides reliable and specific detection of MAP1LC3A in various experimental settings.MAP1LC3A, a mammalian homolog of yeast Atg8, is essential for autophagy, a cellular process crucial for maintaining cellular homeostasis and responding to stressors. Dysregulation of autophagy has been implicated in various diseases, including neurodegenerative disorders and cancer.
Research into the mechanisms of MAP1LC3A function can offer insights into potential therapeutic targets for these conditions.With its high specificity and sensitivity, the MAP1LC3A Polyclonal Antibody (CAB11438) is a valuable tool for researchers seeking to elucidate the role of autophagy in health and disease. Its application extends to studies in cell biology, molecular biology, and pharmacology, offering a comprehensive approach to understanding the intricate processes of autophagy regulation.
Product Name:
MAP1LC3A Rabbit Polyclonal Antibody
SKU:
CAB11438
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MAP1LC3A (NP_115903.1).
Sequence:
MPSD RPFK QRRS FADR CKEV QQIR DQHP SKIP VIIE RYKG EKQL PVLD KTKF LVPD HVNM SELV KIIR RRLQ LNPT QAFF LLVN QHSM VSVS TPIA DIYE
MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis.
Purification Method:
Affinity purification
Gene ID:
84557
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using MAP1LC3A Rabbit pAb (CAB11438) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
