MANF Rabbit Polyclonal Antibody (CAB7005)
- SKU:
- CAB7005
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | MANF Rabbit Polyclonal Antibody |
SKU: | CAB7005 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-182 of human ARMET/ARP/MANF (NP_006001.5). |
Sequence: | LRPG DCEV CISY LGRF YQDL KDRD VTFS PATI ENEL IKFC REAR GKEN RLCY YIGA TDDA ATKI INEV SKPL AHHI PVEK ICEK LKKK DSQI CELK YDKQ IDLS TVDL KKLR VKEL KKIL DDWG ETCK GCAE KSDY IRKI NELM PKYA PKAA SART DL |
Tested Applications: | WB IHC-P IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | ARP; ARMET; ARMET/ARP/MANF |
Positive Sample: | HT-29,HepG2,BxPC-3,Mouse testis,Rat liver,Rat testis,Rat pancreas |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 21kDa |
Observed MW: | 16kDa |
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.
Purification Method: | Affinity purification |
Gene ID: | 7873 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |