The MANF Polyclonal Antibody (CAB7005) is a high-quality antibody designed for research involving mesencephalic astrocyte-derived neurotrophic factor (MANF), a protein known for its neuroprotective properties. Raised in rabbits, this antibody is highly reactive with human samples and is validated for use in Western blot applications. It specifically binds to MANF, allowing for accurate detection and analysis in various cell types.MANF is a unique protein that has been shown to play a crucial role in protecting neurons from degeneration and promoting cell survival in conditions of stress.
Research on MANF has implications for neurodegenerative diseases such as Parkinson's and Alzheimer's, as well as other neurological disorders. By understanding the function of MANF and its interactions in the body, researchers can develop targeted therapies to treat these debilitating conditions.The MANF Polyclonal Antibody is a valuable tool for studying the role of MANF in neuroprotection and neurodegeneration. Its specificity and reliability make it an essential component for researchers investigating the potential therapeutic applications of MANF in the field of neuroscience.
Product Name:
MANF Rabbit Polyclonal Antibody
SKU:
CAB7005
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-182 of human ARMET/ARP/MANF (NP_006001.5).
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.
Purification Method:
Affinity purification
Gene ID:
7873
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using ARMET/ARP/MANF Rabbit pAb (CAB7005) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
