The MANBA Polyclonal Antibody (CAB15289) is a vital tool for researchers studying MANBA, an enzyme involved in lysosomal degradation of glycoconjugates. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the MANBA protein, this antibody enables precise detection and analysis in a variety of cell types, making it an excellent choice for studies focusing on lysosomal function, glycosylation disorders, and related metabolic pathways.
MANBA plays a crucial role in the breakdown of complex carbohydrates within lysosomes, and its dysregulation is linked to lysosomal storage disorders and other metabolic diseases. Investigating the function and regulation of MANBA is essential for understanding these conditions and developing potential therapeutic strategies to target lysosomal dysfunction. With its specificity and reliability, the MANBA Polyclonal Antibody is an invaluable tool for advancing research in these areas.
Product Name:
MANBA Rabbit Polyclonal Antibody
SKU:
CAB15289
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 18-300 of human MANBA (NP_005899.3).
This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with beta-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement.
Purification Method:
Affinity purification
Gene ID:
4126
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MANBA Rabbit pAb (CAB15289) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
