The MAN2B2 Polyclonal Antibody (PAC010354) is a valuable tool for researchers studying MAN2B2, a key enzyme involved in lysosomal metabolism. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples and is validated for use in immunohistochemistry applications. By targeting the MAN2B2 protein, this antibody enables the detection and analysis of lysosomal metabolism in various cell types, making it an essential tool for research in biochemistry and cellular biology.MAN2B2, also known as alpha-mannosidase II, plays a crucial role in glycoprotein processing within the lysosome, impacting cellular functions such as protein degradation and recycling.
Dysregulation of MAN2B2 activity has been implicated in lysosomal storage disorders and other metabolic diseases, highlighting its importance in cellular homeostasis. Studying the function of MAN2B2 is essential for elucidating its role in disease pathogenesis and developing targeted therapies for lysosomal-related disorders.
mannosidase, alpha, class 2B, member 2;MAN2B2;KIAA0935 ;
UniProt Protein Function:
MAN2B2: Belongs to the glycosyl hydrolase 38 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.2.1.24; Secreted, signal peptide; Glycan Metabolism - other glycan degradation; Hydrolase; SecretedChromosomal Location of Human Ortholog: 4p16.1Molecular Function: zinc ion binding; carbohydrate binding; alpha-mannosidase activityBiological Process: mannose metabolic process
