MAN2B1 Rabbit Polyclonal Antibody (CAB9937)
- SKU:
- CAB9937
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | MAN2B1 Rabbit Polyclonal Antibody |
SKU: | CAB9937 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 640-850 of human MAN2B1 (NP_000519.2). |
Sequence: | TFFW YNAS IGDN ESDQ ASGA YIFR PNQQ KPLP VSRW AQIH LVKT PLVQ EVHQ NFSA WCSQ VVRL YPGQ RHLE LEWS VGPI PVGD TWGK EVIS RFDT PLET KGRF YTDS NGRE ILER RRDY RPTW KLNQ TEPV AGNY YPVN TRIY ITDG NMQL TVLT DRSQ GGSS LRDG SLEL MVHR RLLK DDGR GVSE PLME NGSG AWVR GRHL VLLD TAQ |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | MANB; LAMAN; MAN2B1 |
Positive Sample: | Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Lysosome. |
Calculated MW: | 114kDa |
Observed MW: | 170kDa |
This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 4125 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |