The MAN1A1 Polyclonal Antibody (CAB10830) is a valuable tool for researchers studying MAN1A1, an integral membrane protein involved in protein glycosylation and quality control in the endoplasmic reticulum. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications.MAN1A1 plays a crucial role in the processing and maturation of glycoproteins, making it a key player in various cellular processes. Dysregulation of MAN1A1 has been linked to diseases like cancer, neurodegenerative disorders, and developmental abnormalities.
By utilizing the MAN1A1 Polyclonal Antibody, researchers can investigate the function and localization of MAN1A1 in different cell types and explore its potential as a therapeutic target.With its ability to specifically bind to the MAN1A1 protein, this antibody enables precise detection and analysis, making it an essential component in studies focusing on protein glycosylation, protein folding, and cellular quality control mechanisms. By furthering our understanding of MAN1A1, researchers can uncover new insights into disease pathogenesis and potentially uncover novel treatment strategies.
Product Name:
MAN1A1 Rabbit Polyclonal Antibody
SKU:
CAB10830
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 70-190 of human MAN1A1 (NP_005898.2).
Golgi apparatus membrane, Single-pass type II membrane protein.
Calculated MW:
73kDa
Observed MW:
73kDa
This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis of three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases.
Purification Method:
Affinity purification
Gene ID:
4121
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MAN1A1 Rabbit pAb (CAB10830) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
