MAML2 Rabbit Polyclonal Antibody (CAB17225)
- SKU:
- CAB17225
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | MAML2 Rabbit Polyclonal Antibody |
SKU: | CAB17225 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 750-850 of human MAML2 (NP_115803.1). |
Sequence: | NQQL MGKK QTLQ RQIM EQKQ QLLL QQQM LADA EKIA PQDQ INRH LSRP PPDY KDQR RNVG NMQP TAQY SGGS STIS LNSN QALA NPVS THTI LTPN SSLL S |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | MAM2; MAM3; MAM-3; MLL-MAML2; MAML2 |
Positive Sample: | A-549,293T,Mouse brain,Mouse lung |
Cellular Localization: | nuclear speck, nucleoplasm, nucleus |
Calculated MW: | 125kDa |
Observed MW: | 150kDa |
The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed.
Purification Method: | Affinity purification |
Gene ID: | 84441 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |