The MAML2 Polyclonal Antibody (CAB17225) is a valuable tool for researchers studying MAML2, a transcriptional coactivator involved in Notch signaling pathway and implicated in various cancers and developmental disorders. This antibody, generated in rabbits, demonstrates high specificity and sensitivity towards human samples, making it ideal for Western blot applications.MAML2, known for its role in promoting cellular proliferation and differentiation, is a key player in the regulation of gene expression and cellular processes. Its dysregulation has been linked to tumorigenesis and various disease conditions, making it a promising target for therapeutic interventions.
The MAML2 Polyclonal Antibody enables researchers to detect and analyze MAML2 protein levels in different cell types, aiding in the investigation of its function in cancer biology and developmental processes.By utilizing this antibody, researchers can gain valuable insights into the molecular mechanisms underlying MAML2-mediated signaling pathways and its potential implications in disease pathogenesis. This versatile tool is essential for advancing our understanding of MAML2 biology and developing targeted therapies for diseases associated with MAML2 dysregulation.
Product Name:
MAML2 Rabbit Polyclonal Antibody
SKU:
CAB17225
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 750-850 of human MAML2 (NP_115803.1).
The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed.
Purification Method:
Affinity purification
Gene ID:
84441
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MAML2 Rabbit pAb (CAB17225) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
