The MAML1 Polyclonal Antibody (CAB17060) is a valuable tool for researchers studying MAML1, a transcription coactivator involved in Notch signaling pathways. This antibody, derived from rabbit serum, demonstrates high reactivity with human samples and is validated for use in Western blotting experiments. By binding specifically to the MAML1 protein, this antibody allows for precise detection and analysis across various cell types, making it an essential component in studies related to gene regulation and cellular signaling.MAML1, also known as Mastermind Like Transcriptional Coactivator 1, plays a crucial role in various cellular processes, including cell differentiation and proliferation.
Its interactions with Notch receptors contribute to the regulation of gene expression, making it a target of interest in research areas such as developmental biology and cancer biology. Understanding the function of MAML1 is essential for uncovering its potential implications in diseases and identifying therapeutic strategies that target this signaling pathway.
Product Name:
MAML1 Rabbit Polyclonal Antibody
SKU:
CAB17060
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human MAML1 (NP_055572.1).
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.
Purification Method:
Affinity purification
Gene ID:
9794
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MAML1 Rabbit pAb (CAB17060) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
