MALT1 Rabbit Polyclonal Antibody (CAB2144)
- SKU:
- CAB2144
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
Product Name: | MALT1 Rabbit Polyclonal Antibody |
SKU: | CAB2144 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 125-450 of human MALT1 (NP_776216.1). |
Sequence: | PGIK ITVN PESK AVLA GQFV KLCC RATG HPFV QYQW FKMN KEIP NGNT SELI FNAV HVKD AGFY VCRV NNNF TFEF SQWS QLDV CDIP ESFQ RSVD GVSE SKLQ ICVE PTSQ KLMP GSTL VLQC VAVG SPIP HYQW FKNE LPLT HETK KLYM VPYV DLEH QGTY WCHV YNDR DSQD SKKV EIII DELN NLGH PDNK EQTT DQPL AKDK VALL IGNM NYRE HPKL KAPL VDVY ELTN LLRQ LDFK VVSL LDLT EYEM RNAV DEFL LLLD KGVY GLLY YAGH GYEN FGNS FMVP VDAP NPYR SENC LCVQ NILK LMQE KETG LNVF LL |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | MLT; MLT1; IMD12; PCASP1; MALT1 |
Positive Sample: | HeLa,293T |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, perinuclear region. |
Calculated MW: | 92kDa |
Observed MW: | 102kDa |
This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes in mucosa-associated lymphoid tissue lymphomas, including a t(11;18)(q21;q21) translocation with the baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) locus [BIRC3(API2)-MALT1], and a t(14;18)(q32;q21) translocation with the immunoglobulin heavy chain locus (IGH-MALT1). Alternatively spliced transcript variants have been described for this gene.
Purification Method: | Affinity purification |
Gene ID: | 10892 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |