The MALT1 Polyclonal Antibody (CAB2144) is a valuable tool for researchers studying MALT1, a protein involved in cell signaling and immune response regulation. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the MALT1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in immunology and cancer research.MALT1, also known as mucosa-associated lymphoid tissue lymphoma translocation protein 1, plays a crucial role in immune cell activation and regulation. Dysregulation of MALT1 has been implicated in inflammatory diseases and certain types of lymphomas, making it a promising target for therapeutic interventions.
By investigating the functions of MALT1, researchers can gain insights into the underlying mechanisms of immune-related disorders and potentially identify new treatment strategies.Overall, the MALT1 Polyclonal Antibody is a valuable tool for scientists seeking to understand the role of MALT1 in health and disease. Its high specificity and sensitivity make it a reliable choice for research applications aimed at unraveling the complex functions of this key protein in the immune system.
Product Name:
MALT1 Rabbit Polyclonal Antibody
SKU:
CAB2144
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 125-450 of human MALT1 (NP_776216.1).
This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes in mucosa-associated lymphoid tissue lymphomas, including a t(11;18)(q21;q21) translocation with the baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) locus [BIRC3(API2)-MALT1], and a t(14;18)(q32;q21) translocation with the immunoglobulin heavy chain locus (IGH-MALT1). Alternatively spliced transcript variants have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
10892
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MALT1 Rabbit pAb (CAB2144) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
