The Major Vault Protein Polyclonal Antibody (CAB1980) is a valuable tool for researchers studying the Major Vault Protein (MVP), a key component of cellular vaults believed to play a role in multidrug resistance and cellular transport mechanisms. This antibody is produced in rabbits and shows high reactivity to human samples, making it suitable for Western blot applications. By binding specifically to MVP, this antibody enables accurate detection and analysis of MVP expression in a variety of cell types, making it an essential tool for studies in the fields of drug resistance, cellular transport, and cancer research.
The Major Vault Protein is a highly conserved protein that is widely expressed in various tissues and has been linked to drug resistance in cancer cells. By understanding the mechanisms of MVP and its role in cellular function, researchers may uncover new strategies for overcoming drug resistance in cancer treatment. This antibody is a valuable resource for scientists seeking to further explore the functions of MVP and its potential implications for cancer therapy and drug development.
Product Name:
MVP Rabbit Polyclonal Antibody
SKU:
CAB1980
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human MVP (NP_005106.2).
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
9961
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from NIH/3T3 cells, using MVP Rabbit pAb (CAB1980) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
