Prion Protein Rabbit Polyclonal Antibody (CAB2583)
The Major Prion Protein Polyclonal Antibody (CAB2583) is a valuable tool for research involving the major prion protein, a protein implicated in prion diseases such as Creutzfeldt-Jakob disease. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to the major prion protein, this antibody enables detection and analysis of the protein in various cell types, providing researchers with a powerful tool for studying prion diseases and exploring potential therapeutic interventions.
The major prion protein, also known as PrP, is a key player in the pathogenesis of prion diseases, which are fatal neurodegenerative disorders characterized by the accumulation of misfolded prion proteins in the brain. Understanding the role of the major prion protein in these diseases is essential for developing diagnostic tools and therapeutic strategies to combat them. The Major Prion Protein Polyclonal Antibody (CAB2583) offers researchers a reliable means of studying the major prion protein and advancing our understanding of prion diseases.
Product Name:
Prion Protein Rabbit Polyclonal Antibody
SKU:
CAB2583
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 23-230 of human Prion Protein (NP_001073592.1).
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5621
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Prion Protein Rabbit pAb (CAB2583) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
