MAGI2 Antibody (PACO55198)
- SKU:
- PACO55198
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
MAGI2 Antibody (PACO55198)
The MAGI2 Polyclonal Antibody (PACO55198) is a vital tool for researchers studying the MAGI2 protein, known for its involvement in cell signaling pathways and its potential role in cancer development. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the MAGI2 protein, researchers can accurately detect and analyze its expression in various cell types, providing valuable insights for cancer and cell signaling research.
MAGI2, a multi-domain scaffolding protein, is essential for maintaining cell polarity and regulating cell proliferation and migration. Dysregulation of MAGI2 has been linked to the progression of various cancers, making it a promising target for therapeutic interventions. Investigating the functions of MAGI2 with the help of this antibody can lead to a better understanding of its role in cancer biology and the development of targeted cancer therapies.
| Antibody Name: | MAGI2 Antibody (PACO55198) |
| Antibody SKU: | PACO55198 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 protein (1308-1455AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO55198 at dilution of 1:100. |
 | Immunofluorescent analysis of A549 cells using PACO55198 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. |
| Synonyms: | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Atrophin-1-interacting protein 1) (AIP-1) (Atrophin-1-interacting protein A) (Membrane-associated guanylate kinase inverted 2) (MAGI-2), MAGI2, ACVRINP1 AIP1 KIAA0705 |
| UniProt Protein Function: | Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q86UL8 |
| NCBI GenInfo Identifier: | 88909269 |
| NCBI Gene ID: | 9863 |
| NCBI Accession: | Q86UL8.3 |
| UniProt Secondary Accession: | Q86UL8,O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1 A4D1C1, A7E2C3 |
| UniProt Related Accession: | Q86UL8 |
| Molecular Weight: | 157,236 Da |
| NCBI Full Name: | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 |
| NCBI Synonym Full Names: | membrane associated guanylate kinase, WW and PDZ domain containing 2 |
| NCBI Official Symbol: | MAGI2Â Â |
| NCBI Official Synonym Symbols: | AIP1; AIP-1; ARIP1; SSCAM; MAGI-2; ACVRIP1Â Â |
| NCBI Protein Information: | membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 |
| UniProt Protein Name: | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 |
| UniProt Synonym Protein Names: | Atrophin-1-interacting protein 1; AIP-1; Atrophin-1-interacting protein A; Membrane-associated guanylate kinase inverted 2; MAGI-2 |
| Protein Family: | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein |
| UniProt Gene Name: | MAGI2Â Â |
| UniProt Entry Name: | MAGI2_HUMAN |
| Antibodies |
| MAGI2 Antibody (PACO05831) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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