The MAGI2 Antibody (PAC021890) is a key tool for researchers studying MAGI2, a protein involved in cell signaling pathways and cell adhesion. This polyclonal antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to MAGI2, this antibody enables researchers to detect and analyze the protein in various cell types, making it an essential tool for research in cell biology and cancer studies.MAGI2, also known as membrane-associated guanylate kinase inverted 2, plays a crucial role in cell adhesion and cell junction formation.
Its involvement in cell signaling makes it a promising target for research into cancer metastasis and cell migration. Understanding the function of MAGI2 is essential for developing targeted therapies that could disrupt cancer cell proliferation and metastasis.Overall, the MAGI2 Antibody is a valuable tool for researchers seeking to unravel the role of MAGI2 in cellular processes and potentially discover new targets for cancer treatment and cell biology research.
Antibody Name:
MAGI2 Antibody (PACO21890)
Antibody SKU:
PACO21890
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from internal of human MAGI2.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Devroe E., J. Biol. Chem. 279:24444-24451(2004).
Clonality:
Polyclonal
Conjugate:
Non-conjugated
Western blot analysis of extracts from HT-29 cells, using MAGI2 antibody.
Synonyms:
Atrophin-1 interacting protein 1; Atrophin-1 interacting protein A; KIAA0705; MAGI-2; MAGI2
UniProt Protein Function:
Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008]
